This weekend’s Premier League games kick-off at White Hart Lane, where Tottenham host Newcastle.

The game is a big one at both ends of the table. The home side are looking to move closer to third place Chelsea and are just one point behind the Blues.

Tottenham will also be hoping to stretch their three point lead on fifth place Everton to six points, with the Toffee’s not playing until Sunday. Spurs form has been patchy of late, but they won last time out at West Brom.

The home side are without striker Jermain Defoe, who will be out for up to three weeks. Which means that striker Emmanuel Adebayor could start up front as the lone striker.

The visitors have won the last two Premier League games to move six points clear of the relegation zone, with new signing Moussa Sissoko making a big impact. The trip to north London will prove to be a big challenge for the Magpies though.

Elsewhere, champions Manchester City visit strugglers Southampton in the late kick-off. The Saints are just three points clear of the relegation zone and in desperate need of maximum points to move themselves clear of the drop zone.

The home side are yet to win under new boss Mauricio Pochettino and will face a tough task to achieve a win against the champions.

The champions arrive at St Mary’s ten points behind arch-rivals and league leaders Manchester United. This is a must win game for Roberto Mancini’s team, as if they fail to win they could find themselves even further behind the Red Devils.

City have won four out of their last six top flight games, but have drawn their last two encounters in the top flight. The Citizens can’t afford to slip-up again on the south coast.

Other Premier League fixtures:

Chelsea vs. Wigan

Norwich vs. Fulham

Stoke vs. Reading

Sunderland vs. Arsenal

Swansea vs. QPR

Can Manchester City cut the gap on Manchester United?