The early kick-off sees Manchester United host Arsenal at Old Trafford.
The home side recorded an incredible 8-2 victory over the Gunners last season and will be looking for another victory against Arsene Wenger’s side in this clash.
Arsenal are in much better shape than they were in that fixture and the Gunners will be confident of picking up points in Manchester.
United won their last Premier League game 3-2 at Chelsea. An understrength Red Devils side were beaten by the Blues 5-3 after extra-time in the Capitol One Cup on Wednesday.
Arsenal claimed an incredible 7-5 extra-time victory at Reading in the same competition and won 1-0 against QPR in their last Premier League outing. Both teams have injury problems. United are without Shinji Kagawa and Nemanja Vidic, who are both long-term injury concerns.
Better news for United is that young defenders Phil Jones and Chris Smalling are closer to a return, but this game will come too soon for the England duo.
Arsenal are without the likes of Kieran Gibbs, Wojciech Szczesny and Abou Diaby for the clash. England starlet Alex Oxlade-Chamberlain is also a doubt. Full-back Bacary Sagna and midfielder Jack Wilshere are in contention after recently coming back long-term injuries.
Elsewhere, Premier League leaders Chelsea head to Swansea’s Liberty Stadium. The Blues will be looking to bounce back from that first league defeat of the season against United with a win in Wales. Although the Blues did claim some revenge against the Red Devils with a Capitol One Cup victory.
The Swans have a strong home record and are looking to continue that against Roberto Di Matteo’s team at the Liberty Stadium. Swansea will be without injured keeper Michel Vorm. The Dutchman will be replaced by Gerard Tremmel in goal.
Chelsea skipper John Terry is still suspended, but Fernando Torres and Branislav Ivanovic return from one-match bans served in the midweek Capitol One Cup clash.
Saturday’s Premier League fixtures
Fulham vs. Everton
Norwich vs. Stoke
Sunderland vs. Aston Villa
Tottenham vs. Wigan
West Ham vs. West Ham
Can Arsenal defeat Manchester United at Old Trafford?
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