Norwich faces a difficult away trip to Champions League chasing Arsenal on Saturday.
The Canaries are just four points clear of the relegation zone, after a poor run of form.
Meanwhile, the Gunners have the opportunity to move up to third in the Premier League table with victory over Norwich, as Chelsea and Tottenham do not play in the league this weekend.
Aston Villa could move five points clear of the relegation zone with a victory over Fulham at Villa Park. However, third from bottom Wigan have a game in-hand, as the Latics face Millwall in the FA Cup final tomorrow.
The visitors are comfortably in midtable in the Premier League table. Martin Jol’s team will want to finish the season in a strong manner though.
Everton will be looking to close the gap on the teams above them in the race for Champions League football with a victory over struggling QPR. The Toffee’s are six points behind the top four teams and need a win against the Hoops to keep pace with their rivals.
QPR now look doomed to life in the Championship next season, as they are now seven points away from safety.
Southampton host West Ham at St Marys Stadium. One more win would realistically secure both sides Premier League status for another season. Both will be going all out for maximum points on the south coast.
On Sunday, north east rivals Newcastle and Sunderland meet at St James Park. The home side are five points clear of the relegation zone. A win would move the Magpies further clear of the drop zone.
The Black Cats are only outside the relegation zone on goal difference. New boss Sunderland Paolo Di Canio will be looking for his first victory in charge at the Stadium of Light.
Other Premier League fixtures:
Reading vs. Liverpool
Stoke vs. Manchester United
Who will gain the advantage at the bottom of the Premier League this weekend?
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