This weekend’s two biggest Premier League games take place on Sunday.

In the early kick-off Everton play hosts to arch-rivals Liverpool at Goodison Park. Everton have an uncharacteristically good start to their Premier League campaign.

However, Everton look set to be without three first team regulars for the visit of the Reds.

Influential midfielder Steven Pienaar is suspended and fellow midfielders Darron Gibson and Marouane Fellaini could also miss out.

Liverpool could be without right-back Glen Johnson and keeper Pepe Reina is a doubt after missing last weekend’s home game with Reading. Should he miss out Australian Brad Jones will be fill in for the Spaniard.

The Merseyside derby has produced a record 20 red cards in the Premier League era. This encounter will no doubt be no different and a feisty affair.

In one of the later kick-offs Chelsea host Manchester United at Stamford Bridge. The Blues are top of the Premier League table, four points clear of second place Manchester United. Chelsea have made a superb start to the season with seven wins from eight games.

Chelsea have the joint best defensive record in the top flight along with Arsenal. However the visitors are the top scorers in the Premier League. This season though Sir Alex Ferguson’s side have looked vulnerable at the back.

United have a good recent record against Chelsea, winning four and drawing one out of the last five games against the Blues. Their record at Stamford Bridge however isn’t so impressive, winning just once in the last 12 visits.

Other Premier League games:

Saturday

Arsenal vs. QPR

Aston Villa vs. Norwich

Manchester City vs. Swansea

Reading vs. Fulham

Wigan vs. West Ham

Sunday

Newcastle vs. West Brom

Southampton vs. Tottenham

What is the biggest game of this weekend’s Premier League fixtures?